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General: Ciprofloxacin crystals have been observed rarely in the urine of human subjects but more frequently in the urine of laboratory animals, which is usually alkaline. Crystalluria related to ciprofloxacin has been reported only rarely in humans because human urine is usually acidic. Avoid alkalinity of the urine in patients receiving ciprofloxacin. Hydrate patients well to prevent the formation of highly concentrated urine.
Quinolones, including ciprofloxacin, may also cause CNS events, including nervousness, agitation, insomnia, anxiety, nightmares or paranoia.
Alteration of the drug regimen is necessary for patients with renal function impairment.
Moderate to severe phototoxicity manifested as an exaggerated sunburn reaction has been observed in patients who are exposed to direct sunlight while receiving some quinolone antibiotics. Avoid excessive sunlight. Discontinue therapy if phototoxicity occurs.
As with any potent drug, periodic assessment of organ system functions, including renal, hepatic and hematopoietic function, is advisable during prolonged therapy.
Ciprofloxacin intake can interfere with one's ability to drive an automobile or operate machinery. Use Ciprofloxacin with caution in such instances and in activities where a person may be requiring mental alertness and coordination.
